NASA Wallops Flight Facility Air-Sea Interaction Research Facility

This publication serves as an introduction to the Air-Sea Interaction Research Facility at NASA/GSFC/Wallops Flight Facility. The purpose of this publication is to provide background information on the research facility itself, including capabilities, available instrumentation, the types of experiments already done, ongoing experiments, and future plans

A new view of nonlinear water waves: the Hilbert spectrum

We survey the newly developed Hilbert spectral analysis method and its applications to Stokes waves, nonlinear wave evolution processes, the spectral form of the random wave field, and turbulence. Our emphasis is on the inadequacy of presently available methods in nonlinear and nonstationary data analysis. Hilbert spectral analysis is here proposed as an alternative. This new method provides not only a more precise definition of particular events in time-frequency space than wavelet analysis, but also more physically meaningful interpretations of the underlying dynamic processes

A self-zeroing capacitance probe for water wave measurements

The wave probe developed at the Air-Sea Interaction Research Facility was designed to measure the surface elevation fluctuations of water waves. Design criteria included being linear in response, self-zeroing to the mean water level, having multiple operating ranges so that the instrument's maximum output could be matched to the maximum surface elevation over varying conditions, and be as noise-free as possible. The purpose of this publication is to provide a detailed description of the design and construction of this probe

Wideband Loop Antenna with Electronically Switchable Circular Polarization

This paper presents a novel printed antenna with wide bandwidth, high gain and reconfigurable circular polarizations. A loop antenna is printed on both sides of a dielectric substrate: a dual PIN diode loaded loop is printed on one side while a dual gap loaded smaller loop is printed on the other side. By controlling the ON/OFF states of the PIN diodes, the polarization of the proposed antenna can be switched electronically to right-hand circular polarization (RHCP) or left-hand circular polarization (LHCP) over a wideband frequency range. A prototype is fabricated and measured to verify the performance of the antenna. The measured results indicate that the antenna achieves an impedance bandwidth of over 30%, and a 3-dB axial ratio (AR) bandwidth of 12.7% and 14.9% for RHCP and LHCP, respectively. The measured gain is around 8 dBic for LHCP state and 7 dBic for RHCP state. Due to advantages of wide overlapped bandwidth, simple feeding structure and high gain, this antenna is promising for applications in dual-CP wireless communication systems

Planar Ultra-Thin Small Beam-Switching Antenna

A novel planar ultrathin electronically steerable parasitic array radiator (ESPAR) is presented in this paper. Through theoretical analysis of the electric fields of orthogonally crossed dipoles in phase quadrature, it is found that the crossed dipoles radiate linearly polarized wave with a rotational electric field in the azimuth plane. This characteristic is then utilized to design a planar crossed dipole ESPAR, termed as “CD-ESPAR.” Furthermore, a simple but effective impedance matching method is also proposed and analyzed. To verify these concepts, a prototype with compact size and very low profile (0.42 ?0 × 0.42 ?0 ×0.006 ?0) resonating at 2.3 GHz is designed, fabricated, and measured. The measured results indicate that the proposed antenna achieves more than 17.8% impedance bandwidth and can produce four directional beams, covering the whole azimuth plane. Owing to its planar ultrathin structure, compact size, electronically beam-switching ability, low power, and low cost characteristics, it is promising for applications in wireless communication

High-Reliability Waveguide Vacuum/Pressure Window

The NASA Deep Space Network (DSN) uses commercial waveguide windows on the output waveguide of Ka-band (32 GHz) low-noise amplifiers. Mechanical failure of these windows resulted in an unacceptable loss in tracking time. To address this issue, a new Ka-band WR-28 waveguide window has been designed, fabricated, and tested. The window uses a slab of low-loss, low-dielectric constant foam that is bonded into a 1/2-wave-thick waveguide/flange. The foam is a commercially available, rigid, closed-cell polymethacrylimide. It has excellent electrical properties with a dielectric constant of 1.04, and a loss tangent of 0.01. It is relatively strong with a tensile strength of 1 MPa. The material is virtually impermeable to helium. The finished window exhibits a leak rate of less than 3x10(exp -3)cu cm/s with helium. The material is also chemically resistant and can be cleaned with acetone. The window is constructed by fabricating a window body by brazing a short length of WR-28 copper waveguide into a standard rectangular flange, and machining the resulting part to a thickness of 4.6 mm. The foam is machined to a rectangular shape with a dimension of 7.06x3.53 mm. The foam is bonded into the body with a two-part epoxy. After curing, the excess glue and foam are knife-trimmed by hand. The finished window has a loss of less than 0.08 dB (2%) and a return loss of greater than 25 dB at 32 GHz. This meets the requirements for the DSN application. The window is usable for most applications over the entire 26-to-40-GHz waveguide band. The window return loss can be tuned to a required frequency by var y in g the thickness of the window slightly. Most standard waveguide windows use a thin membrane of material bonded into a recess in a waveguide flange, or sandwiched between two flanges with a polymer seal. Designs using the recessed window are prone to mechanical failure over time due to constraints on the dimensions of the recess that allow the bond to fail. Designs using the sandwich method are often permeable to helium, which prohibits the use of helium leak detection. At the time of this reporting, 40 windows have been produced. Twelve are in operation with a combined operating time of over 30,000 hours without a failure

Non-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI.

Coronary artery disease (CAD) causes mortality and morbidity worldwide. We used near-infrared erythrocyte-derived transducers (NETs), a contrast agent, in combination with a photoacoustic imaging system to identify the locations of atherosclerotic lesions and occlusion due to myocardial-infarction (MI). NETs (≈90 nm diameter) were fabricated from hemoglobin-depleted mice erythrocyte-ghosts and doped with Indocyanine Green (ICG). Ten weeks old male C57BL/6 mice (n = 9) underwent left anterior descending (LAD) coronary artery ligation to mimic vulnerable atherosclerotic plaques and their rupture leading to MI. 150 µL of NETs (20 µM ICG,) was IV injected via tail vein 1-hour prior to photoacoustic (PA) and fluorescence in vivo imaging by exciting NETs at 800 nm and 650 nm, respectively. These results were verified with histochemical analysis. We observed ≈256-fold higher PA signal from the accumulated NETs in the coronary artery above the ligation. Fluorescence signals were detected in LAD coronary, thymus, and liver. Similar signals were observed when the chest was cut open. Atherosclerotic lesions exhibited inflammatory cells. Liver demonstrated normal portal tract, with no parenchymal necrosis, inflammation, fibrosis, or other pathologic changes, suggesting biocompatibility of NETs. Non-invasively detecting atherosclerotic plaques and stenosis using NETs may lay a groundwork for future clinical detection and improving CAD risk assessment

Inverted-S Antenna with Wideband Circular Polarization and Wide Axial Ratio Beamwidth

A novel broadband circularly polarized (CP) antenna with wide axial ratio (AR) beamwidth is proposed. It is composed of two curved arms shaped like an inverted “S”. The mechanisms of wideband CP operation and wide AR beamwidth are explained. To validate the concept, a prototype at C-band is manufactured and measured. Experimental results confirm that the antenna achieves an impedance bandwidth of 63% and a CP bandwidth of 42%. Furthermore, maximum AR beamwidth of 140o is achieved and wide AR beamwidth can be maintained in a frequency bandwidth of 35% in nearly all elevation planes. In addition, the antenna has the advantage of being easily extended to arrays. A 4-element array using the proposed antenna is investigated through both simulations and experiments, and achieves 60% CP bandwidth and wide AR beamwidth. The proposed inverted-S antenna can realize wide CP bandwidth and wide AR beamwidth, and is easy to form wideband CP arrays

Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors.

PurposeTo determine the maximum tolerated dose (MTD), toxicities, and pharmacodynamics effects of sirolimus combined with oral metronomic topotecan and cyclophosphamide in a pediatric population.Materials and methodsPatients who were 1 to 30 years of age with relapsed/refractory solid tumors (including CNS) were eligible. Patients received daily oral sirolimus and cyclophosphamide (25-50 mg/m2/dose) on days 1-21 and oral topotecan (0.8 mg/m2/dose) on days 1-14 in 28-day cycles. Sirolimus steady-state plasma trough concentrations of 3-7.9 ng/mL and 8-12.0 ng/mL were evaluated, with dose escalation based on a 3+3 phase 1 design. Biomarkers of angiogenesis were also evaluated.ResultsTwenty-one patients were treated (median age 18 years; range 9-30). Dose-limiting toxicities included myelosuppression, ALT elevation, stomatitis, and hypertriglyceridemia. The MTD was sirolimus with trough goal of 8-12.0 ng/mL; cyclophosphamide 25 mg/m2/dose; and topotecan 0.8 mg/m2/dose. No objective responses were observed. Four patients had prolonged stable disease > 4 cycles (range 4-12). Correlative biomarker analyses demonstrated reductions in thrombospondin-1 (p=0.043) and soluble vascular endothelial growth factor receptor-2 plasma concentrations at 21 days compared to baseline.ConclusionsThe combination of oral sirolimus, topotecan, and cyclophosphamide was well tolerated and biomarker studies demonstrated modulation of angiogenic pathways with this regimen

Evolution of the intercontinental disjunctions in six continents in the Ampelopsis clade of the grape family (Vitaceae)

<p>Abstract</p> <p>Background</p> <p>The <it>Ampelopsis </it>clade (<it>Ampelopsis </it>and its close allies) of the grape family Vitaceae contains ca. 43 species disjunctly distributed in Asia, Europe, North America, South America, Africa, and Australia, and is a rare example to study both the Northern and the Southern Hemisphere intercontinental disjunctions. We reconstruct the temporal and spatial diversification of the <it>Ampelopsis </it>clade to explore the evolutionary processes that have resulted in their intercontinental disjunctions in six continents.</p> <p>Results</p> <p>The Bayesian molecular clock dating and the likelihood ancestral area analyses suggest that the <it>Ampelopsis </it>clade most likely originated in North America with its crown group dated at 41.2 Ma (95% HPD 23.4 - 61.0 Ma) in the middle Eocene. Two independent Laurasian migrations into Eurasia are inferred to have occurred in the early Miocene via the North Atlantic land bridges. The ancestor of the Southern Hemisphere lineage migrated from North America to South America in the early Oligocene. The Gondwanan-like pattern of intercontinental disjunction is best explained by two long-distance dispersals: once from South America to Africa estimated at 30.5 Ma (95% HPD 16.9 - 45.9 Ma), and the other from South America to Australia dated to 19.2 Ma (95% HPD 6.7 - 22.3 Ma).</p> <p>Conclusions</p> <p>The global disjunctions in the <it>Ampelopsis </it>clade are best explained by a diversification model of North American origin, two Laurasian migrations, one migration into South America, and two post-Gondwanan long-distance dispersals. These findings highlight the importance of both vicariance and long distance dispersal in shaping intercontinental disjunctions of flowering plants.</p